// References
Primary literature
Peer-reviewed sources cited throughout the course. Where possible, links go to PubMed or open-access full text.
The Hallmarks of Aging: An Expanding Universe
López-Otín et al., Cell 2023 ↗
Why Longevity, Why Now
Geroscience: linking aging to chronic disease
Kennedy et al., Cell 2014 ↗
Why Longevity, Why Now
Hallmarks of Aging: An Expanding Universe
López-Otín et al., Cell 2023 ↗
The Hallmarks of Aging
The role of cellular senescence in ageing and disease
Di Micco et al., Nat Rev Mol Cell Biol 2021 ↗
The Hallmarks of Aging
Association of Cardiorespiratory Fitness With Long-term Mortality
Mandsager et al., JAMA Network Open 2018 ↗
Exercise — The Most Powerful Geroprotector
Resistance training and mortality risk: meta-analysis
Saeidifard et al., Br J Sports Med 2022 ↗
Exercise — The Most Powerful Geroprotector
Primary Prevention of CVD with a Mediterranean Diet
Estruch et al., NEJM 2018 (PREDIMED) ↗
Nutrition, Fasting & Caloric Restriction
2 years of caloric restriction slows pace of aging
Waziry et al., Nat Aging 2023 ↗
Nutrition, Fasting & Caloric Restriction
Sleep drives metabolite clearance from the adult brain
Xie et al., Science 2013 ↗
Sleep, Stress & Circadian Health
Sleep duration and all-cause mortality meta-analysis
Cappuccio et al., Sleep 2010 ↗
Sleep, Stress & Circadian Health
DunedinPACE: a DNA methylation biomarker of pace of aging
Belsky et al., eLife 2022 ↗
Biomarkers & Biological Age Testing
Apolipoprotein B and cardiovascular disease
Sniderman et al., JAMA Cardiol 2019 ↗
Biomarkers & Biological Age Testing
Rapamycin extends lifespan in genetically heterogeneous mice
Harrison et al., Nature 2009 ↗
Pharmacology of Healthspan
Metformin as a tool to target aging (TAME)
Barzilai et al., Cell Metab 2016 ↗
Pharmacology of Healthspan
Semaglutide and Cardiovascular Outcomes (SELECT)
Lincoff et al., NEJM 2023 ↗
Pharmacology of Healthspan
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
Ocampo et al., Cell 2016 ↗
Frontier Science & Future Therapeutics
Loss of epigenetic information as a cause of mammalian aging
Yang et al., Cell 2023 ↗
Frontier Science & Future Therapeutics
Reprogramming to recover youthful epigenetic information and restore vision
Lu, Brommer, Tian … Sinclair. Nature 2020 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
Loss of epigenetic information as a cause of mammalian aging
Yang, Wei, Macip … Sinclair. Cell 2023 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
DNA breaks relocalize SIR proteins and accelerate aging in yeast
Oberdoerffer & Sinclair, Nat Rev Mol Cell Biol 2007 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
Oberdoerffer et al., Cell 2008 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
Why we age and why we don't have to (Lifespan)
Sinclair & LaPlante, Atria 2019 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
DNA methylation age of human tissues and cell types
Horvath, Genome Biology 2013 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
Small-molecule cocktails reverse aspects of cellular aging in vitro (chemical reprogramming)
Yang et al., Aging 2023 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
Life Biosciences advances LIFE-001 partial epigenetic reprogramming for NAION
Life Biosciences, company press materials ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
Critique: Is aging caused by loss of epigenetic information?
Gladyshev, Aging Cell commentary 2024 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
NAD+ in aging: molecular mechanisms and translational implications
Covarrubias, Perrone, Grozio, Verdin. Nat Rev Mol Cell Biol 2021 ↗
The Information Theory of Aging — Sinclair Lab Deep Dive
The war on aging (foundational essay)
de Grey, Annals NY Acad Sci 2002 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
de Grey & Rae, St. Martin's Press 2007 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Strategies for engineered negligible senescence: why genuine control of aging may be foreseeable
de Grey et al., Annals NY Acad Sci 2004 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Life extension, human rights, and the rational refinement of repugnance
de Grey, J Med Ethics 2005 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Is defeating aging only an irresponsible distraction? — MIT Tech Review SENS challenge
MIT Technology Review 2005–2006 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Allotopic expression of ATP6 rescues complex V deficiency (MitoSENS / SRF)
Boominathan et al., Nucleic Acids Research 2016 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Glucosepane: a poorly understood but quantitatively dominant crosslink
Sell & Monnier; Spiegel-lab synthesis 2015 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
LEV Foundation Robust Mouse Rejuvenation program overview
LEV Foundation ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Hallmarks of aging: an expanding universe (for context vs SENS)
López-Otín et al., Cell 2023 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence
Senolytics: from concept (ApoptoSENS lineage) to clinical translation
Kirkland & Tchkonia, J Intern Med 2020 ↗
Aubrey de Grey & SENS — Engineering Negligible Senescence